Berberine Supplementation, Sprint Interval Training, and Immune Function Study
Completed · Not applicable · Has a placebo group
Conditions studied: Berberine, Sprint Training, Wellbeing, Anaerobic Power, Inflammation Biomarkers, Monocyte Function
In brief
The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?
Key facts
- Study ID
- NCT07480018
- Run by
- University of Northern Colorado
- People needed
- 40
- Starts
- 2026-01-01
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2026-06-05
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and Females
- Aged 18-45
- DASS-21 subscale scores indicating "Mild" or greater category for Depression ≥ 10, Anxiety ≥ 7, and Stress ≥ 11
You may not qualify if…
- Regular berberine intake in the last 2 months
- Performs SIT regularly in the last month
- Pregnant or planning to become pregnant
- Chronic use of anti-inflammatory medication or medications that affect liver metabolism
- Prior history of chronic conditions such as Cardiovascular Disease, Diabetes, and Cancer
- Severe and untreated anxiety or depression
- Severe Peanut Allergies
- Any contraindications to performing high intensity exercise
Where it is running
- University of Northern Colorado — Greeley, Colorado, United States
Full record on ClinicalTrials.gov
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