Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial

Starting soon · Not applicable

Conditions studied: Cardiac Arrest

In brief

When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs. CPR involves a combination of chest compressions (to push the blood) and ventilations (to provide oxygen and gas exchange). There is a lot of research that has helped to optimize the provision of chest compressions, however there is considerably less research available to guide ventilations. The current guideline recommendations are based on limited data, and no data that is specific to cardiac arrest patients. There is a recognized need for research to better guide ventilation during CPR. This research will help to better define appropriate ventilation targets for cardiac arrest patients.

Key facts

Study ID

NCT07479836

Run by

Sunnybrook Health Sciences Centre

People needed

1656

Starts

2026-03-01

Expected to finish

2028-03-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (>=18 years of age)
• presumed cardiac etiology
• treated by paramedics
• Ventilation monitor utilized

You may not qualify if…

• Do Not Resuscitate (DNR) order
• No use of ventilation monitor
• Traumatic cardiac arrest
• Pregnant patients
• Prisoners
• Respiratory cause of cardiac arrest (e.g. drowning, hanging, suffocation, opioid-related)

Where it is running

• Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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