Octreotide Microspheres for Preventing Pancreatic Fistula

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Pancreatic Fistula

In brief

This study is a randomized, double-blind, placebo-controlled, multicenter phase III clinical trial designed to evaluate the efficacy and safety of octreotide microspheres in preventing pancreatic fistula after distal pancreatectomy.

Key facts

Study ID

NCT07479784

Run by

Shanghai Zhongshan Hospital

People needed

230

Starts

2026-04-01

Expected to finish

2028-12-31

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects voluntarily participate in this study and sign the informed consent form;
• Age ≥18 and ≤80 years old, both males and females are eligible;
• Preoperative imaging assessment indicates the corresponding disease is surgically resectable;
• Planned to undergo distal pancreatectomy;
• Female subjects of childbearing potential must agree to use reliable methods of contraception from the time of signing the informed consent form until at least 120 days after administration of the study drug. A negative HCG test result within 7 days prior to initiating study treatment is required, and they must not be lactating;
• Male subjects with partners of childbearing potential must agree to use reliable methods of contraception from the time of signing the informed consent form until at least 120 days after administration of the study drug; during the same period, male patients must also agree not to donate sperm.

You may not qualify if…

• Cirrhosis or chronic active hepatitis;
• Presence of malabsorption syndrome, short bowel syndrome, or choleretic diarrhea that cannot be effectively controlled;
• Acute cholecystitis;
• Uncontrolled infection, or history of immunodeficiency, including a positive HIV test;
• International Normalized Ratio (INR) >1.5, or use of medication affecting prothrombin time (PT) or activated partial thromboplastin time (APTT);
• Patients scheduled for total pancreatectomy;
• History of pancreatic resection surgery;
• Concurrent severe cardiac, pulmonary, hepatic, or renal disease making the patient unfit for surgery;
• Previous treatment with long-acting somatostatin analogues; treatment with somatostatin or short-acting somatostatin analogues within 5 half-lives;
• Known allergy to somatostatin or its analogues;
• Current participation in another clinical trial, except for observational, non-interventional studies or the follow-up period of an interventional study;
• Any condition that, in the investigator's judgment, may pose a risk to the subject from receiving the study drug, or may interfere with the evaluation of the study drug, subject safety, or interpretation of study results.

Full record on ClinicalTrials.gov

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