Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio
Starting soon · Phase 4
Conditions studied: Elderly, Surgery, Depth of Anesthesia, Total Intravenous Anesthesia, Delayed Neurocognitive Recovery
In brief
The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial. In some studies investigating TIVA, anesthesiologists mainly achieve the target depth of anesthesia by adjusting the dose of propofol, whereas the doses of opioids remains comparable between different anesthetic depth groups, possibly resulting inadequate analgesia. This study is aimed to investigate the impact of different anesthesia depths maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio on the incidence of early postoperative neurocognitive complications in older patients undergoing noncardiac surgery.
Key facts
- Study ID
- NCT07479719
- Run by
- Peking University First Hospital
- People needed
- 200
- Starts
- 2026-04-01
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-03-18
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged ≥ 65 years.
- Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia.
- Require patient-controlled intravenous analgesia after surgery.
- Provide written informed consent.
You may not qualify if…
- Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons.
- Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.
- Traumatic brain injury or neurosurgery.
- Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR <30 ml/min/1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV).
- Planned ICU admission with endotracheal intubation after surgery.
- Enrolled in the other studies.
- Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.
Where it is running
- Peking University First Hospital — Beijing, Beijing Municipality, China
Full record on ClinicalTrials.gov
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