Modified Shock Index

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Conditions studied: Sepsis

In brief

The Emergence of Modified Shock Index (MSI) To further enhance the assessment of hemodynamic stability, the modified shock index (MSI) was developed. The MSI is defined as the ratio of heart rate to mean arterial pressure (MAP) This index takes into account the effect of diastolic blood pressure by replacing SBP with MAP in the calculation . The modified shock index has proven to be a superior predictor of mortality compared to traditional SI . It outperforms heart rate, systolic blood pressure, diastolic blood pressure, and SI as individual predictors

Key facts

Study ID

NCT07479563

Run by

Sohag University

People needed

70

Starts

2026-03-01

Expected to finish

2027-04-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years Presentation to the ED with sepsis(Suspected or confirmed infection plus Evidence of organ dysfunction) (SOFA score ≥ 2 from baseline)

You may not qualify if…

• Pregnancy
• * poly traumatized patients
• * Cardiac arrest on arrival
• * Patients with significant cardiac arrhythmia including atrial fibrillation with rapid ventricular response, or pacemaker-dependent rhythms
• * Patients transferred from another hospital after initial resuscitation

Full record on ClinicalTrials.gov

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