Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery
Recruiting now · Not applicable
Conditions studied: PONV, Cerebellopontine Angle Tumor, Microvascular Decompression Surgery, Postoperative Analgesia
In brief
This single-center, double-blind, randomized controlled trial aims to determine whether oliceridine for patient-controlled intravenous analgesia (PCIA) can significantly reduce the incidence of postoperative nausea, an opioid-related adverse reaction, compared to sufentanil PCIA in patients undergoing cerebellopontine angle (CPA) region surgery. A secondary objective is to compare the postoperative analgesic effects between the two drugs. The study plans to enroll 174 patients (with a calculated sample size of 164 plus 5% for attrition). The primary outcome is the incidence of nausea within 6-48 hours postoperatively. Secondary outcomes include pain scores at rest and during movement within 48 hours, and other exploratory outcomes such as vomiting incidence, time to first flatus/defecation, and gastrointestinal function scores.
Key facts
- Study ID
- NCT07479446
- Run by
- Xuanwu Hospital, Beijing
- People needed
- 174
- Starts
- 2026-03-25
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Scheduled for elective CPA region surgery with planned PCIA.
- Age 18-65 years.
- ASA physical status I-III.
- Provides written informed consent.
You may not qualify if…
- Opioid tolerance (taking opioids ≥1 week, equivalent to oral morphine ≥50 mg/day or oxycodone ≥30 mg/day).
- Severe cardiopulmonary, hepatic, renal, vascular, neurological, hematological, gastrointestinal, or endocrine diseases.
- Postoperative ICU admission with tracheal intubation.
- BMI ≤18.5 or ≥30 kg/m².
- Participation in another clinical trial within 3 months prior to screening.
Where it is running
- Xuanwu Hospital, Capital Medical University — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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