Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC

Recruiting now · Not applicable

Conditions studied: Non-Small Cell Lung Cancer, Postoperative Air Leak, NSCLC

In brief

This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.

Key facts

Study ID: NCT07479277
Run by: Fondazione del Piemonte per l'Oncologia
People needed: 160
Starts: 2026-02-27
Expected to finish: 2027-12-31
Last updated by the study team: 2026-03-18

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥18 years
Written informed consent
Planned VATS upper or lower lobectomy for NSCLC
Minimally invasive thoracoscopic approach
Middle lobectomy excluded

You may not qualify if…

Induction radiochemotherapy or chemo-immunotherapy
Severe COPD: GOLD 3 or higher
Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc.
Albumin intolerance/allergy
Renal insufficiency
Redo surgery
Use of sealants/adhesives other than the study approach
Expected extensive pleural adhesions

Where it is running

Unità di Chirurgia Toracica Oncologica — Candiolo, Torino, Italy (enrolling)
Ospedale centrale di Bolzano, Chirurgia Toracica e Vascolare — Bolzano, Italy
Azienda Ospedaliero-Universitaria Careggi — Florence, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico — Milan, Italy
Irccs Ismett — Palermo, Italy
Azienda Ospedaliera-Universitaria Pisana — Pisa, Italy

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.