Effects of P24 on Postprandial Aminoacidemia
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Postprandial Amino Acid Concentrations in Healthy Adults
In brief
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia following consumption of a standardized mixed-protein meal containing both plant- and animal-derived protein sources. Secondary objectives include evaluating the postprandial plasma peptidomic response, characterizing the postprandial hormonal responses (GLP-1, insulin, and GIP), and assessing the postprandial glucose response using standardized capillary blood glucose measurements. The study will also evaluate subjective responses including satiety and hunger and gastrointestinal symptoms.
Key facts
- Study ID
- NCT07479173
- Run by
- Amplifye
- People needed
- 30
- Starts
- 2026-08-17
- Expected to finish
- 2027-12-15
- Last updated by the study team
- 2026-08-07
Who can join
Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy adults aged 45-75 years
- BMI 18.5-35 kg/m2
- Able to provide informed consent and comply with study procedure
- Willing to consume the standardized mixed-protein test meal
You may not qualify if…
- BMI outside of 18.5-35 kg/m2
- Gastrointestinal disorders or malabsorption syndromes that could affect digestion/absorption (e.g., inflammatory bowel disease, celiac disease)
- Diagnosed diabetes
- Current use of medications or supplements that materially affect glucose metabolism or digestion (e.g., GLP-1 receptor agonists, chronic digestive enzyme supplementation)
- Resting blood pressure ≥ 140/90 mmHg
- Self-reported cancer within past 5 years
- Known allergy or intolerance to meal components or capsule ingredients
- Self-reported anemia or other conditions that increase risk from blood draws
- Pregnancy or breastfeeding
- Current smoking or nicotine use, heavy alcohol use (defined as > 5 drinks/day or > 15 drinks/week), or other factors that in the investigator's judgment make participation unsafe
Where it is running
- Ragle Human Nutrition Center — Davis, California, United States (enrolling)
Full record on ClinicalTrials.gov
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