Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study

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Conditions studied: ALS (Amyotrophic Lateral Sclerosis)

In brief

The search for diagnostic biomarkers that can be used routinely is a major challenge to manage Amyotrophic lateral sclerosis (ALS) in order to characterize the pathophysiology and accelerate the management of the disease. Some non-specific biomarkers have been proposed (Neurofilaments, TDP-43) but their diagnostic value remains controversial. This study aims to identify ALS-specific platelet biomarkers using targeted and untargeted multi-omic approaches, in order to enable differential diagnosis between ALS and other motor neuron diseases.

Key facts

Study ID

NCT07479017

Run by

University Hospital, Tours

People needed

60

Starts

2026-04-01

Expected to finish

2027-08-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with ALS:
• Men or women aged 18 to 75
• ALS diagnosed according to the El Escorial criteria
• ALS diagnosis less than 3 months ago
• Onset of symptoms defined as the time when muscle weakness was first observed by the patient less than 2 years ago
• Controls with another motor neuron disease:
• Men or women aged 18 to 75
• Diagnosis of motor neuron disease < 3 months

You may not qualify if…

• Genetic variants associated with ALS
• Pregnant or breastfeeding women
• Treatment with oral or injectable anticoagulants, antiplatelet agents (EXCEPT aspirin at the maximum authorized dosage of 160 mg per day)
• Uncontrolled diabetes
• Persons deprived of their liberty by judicial or administrative decision
• Persons subject to legal protection measures: guardianship or curatorship
• Opposition to data processing

Where it is running

• University hospital, Limoges — Limoges, France
• University hospital, Lyon — Lyon, France
• university hospital, Tours — Tours, France

Full record on ClinicalTrials.gov

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