Clinical Study of PEG Bowel Preparation in Appendectomy Patients
Recruiting now
Conditions studied: Appendicitis, Appendicitis Acute
In brief
Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol (PEG2000 - 4000) is often used as laxative and lubricant in colonoscopy. However, the widespread use of PEG may cause long-term and irreversible damage to intestinal microorganisms and bring great hidden dangers to health. The appendix has long been regarded as a redundant organ in evolution. The incidence of appendicitis ranks first in surgical acute abdomen. Traditionally, once acute appendicitis is diagnosed, it is usually treated with appendectomy. However, recent studies have revealed that appendectomy may be associated with psychiatric diseases, colorectal cancer, cardiovascular diseases and other diseases. The appendix is not only an important organ of the immune system, but also undertakes the function of storing and protecting intestinal microbes.. . This change may affect the function of the central nervous system through the microbe gut brain axis, and then pose a potential threat to the health and behavior of the host, such as increasing the risk of diseases such as Parkinson's disease. Based on this, this clinical trial aims to investigate (1) the changes of intestinal flora in the appendectomy population before and after colonoscopy in the process of polyethylene glycol intestinal preparation; (2) the differences between the changes of intestinal flora before and after colonoscopy in the appendicectomy population and the normal population in the process of flora recovery.
Key facts
- Study ID
- NCT07478029
- Run by
- Huaping Xie
- People needed
- 10
- Starts
- 2024-02-23
- Expected to finish
- 2027-03-18
- Last updated by the study team
- 2026-03-17
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged 18-75 years.
- Scheduled to undergo colonoscopy.
- Generally healthy without major organ diseases.
- For appendectomy group: history of appendectomy or right hemicolectomy (including appendectomy).
- For control group: no history of appendectomy or right hemicolectomy.
You may not qualify if…
- Allergy or intolerance to PEG laxatives.
- Pregnant or lactating women.
- Mental disorders.
- Use of antibiotics within 6 months prior to study enrollment.
- Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency).
- For control group only: presence of organic diseases.
Where it is running
- Department of Gastroenterology Tongji Hospital, Tongji Medical college, Huazhong University of Science and technology — Wuhan, Hubei, China (enrolling)
Full record on ClinicalTrials.gov
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