Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions

Starting soon · Not applicable

Conditions studied: Periapical Diseases, Root Canal Therapy, Mineral Trioxide Aggregate (MTA)

In brief

The main objective of this study is to compare the healing rate of periapical lesions after non-surgical endodontic retreatment in teeth obturated with gutta-percha versus those obturated with mineral trioxide aggregate (MTA), with a 12-month follow-up. Secondary objectives include evaluating differences between groups in healing time, postoperative pain, and tooth discoloration.

Key facts

Study ID

NCT07477171

Run by

University of Santiago de Compostela

People needed

58

Starts

2026-03-01

Expected to finish

2027-04-01

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥18 years old American Society of Anesthesiologists (ASA) physical status I and II Teeth requiring non-surgical endodontic retreatment Periapical lesion ≤10 mm in maximum diameter on periapical radiograph Apical canal diameter ≤ size 50 Teeth without periodontal defects or mobility

You may not qualify if…

• Smokers Teeth with insufficient remaining tooth structure Teeth requiring surgical retreatment Primary endodontic treatment complications (fractured instrument, perforation, ledge or apical transportation)

Where it is running

• School of Medicine and Dentistry — Santiago de Compostela, A Coruña, Spain

Full record on ClinicalTrials.gov

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