EMS-Initiated Buprenorphine

Starting soon

Conditions studied: Opioid Use Disorder

In brief

This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm prospective trial that will provide preliminary effectiveness data, from which to build a larger randomized control trail (RCT) trial.

Key facts

Study ID

NCT07475728

Run by

Yale University

People needed

495

Starts

2026-06-01

Expected to finish

2029-05-01

Last updated by the study team

2026-05-28

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Treated by the EMS-Initiated buprenorphine clinical protocol which includes:
• Patients that accept EMS-Initiated BUP protocol. Patients offered the EMS-Initiated BUP protocol but declined.1
• Willing to follow study procedures.
• Able to speak English sufficiently to understand study procedures, and to provide verbal and electronic/written consent.

You may not qualify if…

• Patients who lack decision making capacity
• Patients who are in police or protective custody

Where it is running

• Alameda Health System — Oakland, California, United States
• Hennepin Healthcare — Minneapolis, Minnesota, United States
• Cooper University Hospital — Camden, New Jersey, United States

Full record on ClinicalTrials.gov

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