Combination Gerotherapeutic Interventions for Healthspan Improvement
Running, not enrolling · Phase 3 · Has a placebo group
Conditions studied: Healthspan Improvement, Aging, Longevity
In brief
This study is a 90-day interventional, randomized, controlled pilot trial exploring multi-modal gerotherapies and their impact on longevity-related outcomes. In this proof-of-concept phase, a small sample size of up to 30 subjects (10 subjects in each arm) will be randomized into one of the three arms: 1) Control, 2) Multi-therapy (B12, Naltrexone, Metformin, and NAD+), or 4) Comprehensive Therapy (Rapamycin, Naltrexone, Metformin, B12, NAD+, GSH, and Infinite Supplement).
Key facts
- Study ID
- NCT07475546
- Run by
- AgelessRx
- People needed
- 30
- Starts
- 2025-07-23
- Expected to finish
- 2026-04-01
- Last updated by the study team
- 2026-03-16
Who can join
Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- New, existing, or prospective AgelessRx patient
- Adults (60-80 years of age)
- Any sex
- Any ethnicity
- Willingness to provide informed consent and complete study assessments/procedures
- Willingness to attend virtual meeting check-ins/follow-ups
- Willingness and eligibility to take all medications used in this study
- Has at-risk indicators for decline on measures of cognitive, immune, and muscle function, as indicated by a combination of BMI of 26-30; SF36 score below the validated central tendency for 2 of: physical function, physical role limitations, energy, pain; final ISQ scores of <6; individuals that report brain fog or difficulty with mental clarity; pre-diabetic, or other comorbidities that result in reduced overall health functioning as determined by a physician
You may not qualify if…
- Pregnant or breastfeeding individuals
- History of severe adverse reactions to study medications
- Significant psychiatric illness that may affect participation
- Determination of ineligibility for a study medication by AgelessRx medical team
- Concurrent participation in other conflicting clinical trials
Where it is running
- AgelessRx — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.