Exercise-Based Strategies for Chronic Back Pain

Starting soon · Not applicable

Conditions studied: Chronic Low-back Pain (cLBP)

In brief

This randomized, controlled, five-arm, parallel-group trial will evaluate the effects of 8 weeks of supervised resistance training and developmental position-based exercise, with or without real-time non-invasive intra-abdominal pressure biofeedback, in adults aged 40 to 60 years with chronic low back pain. The trial will compare supervised gym-based agonist-antagonist paired set resistance training with OHMTRACK, supervised gym-based resistance training without OHMTRACK, supervised physiotherapy-based developmental exercise with OHMTRACK, home-based developmental exercise with OHMTRACK, and an active control condition. Primary outcomes will assess changes in pain and physical function after the intervention. Secondary outcomes will include neuromuscular coordination, postural stabilization, cardiovascular, respiratory, metabolic, behavioral, feasibility, and follow-up outcomes.

Key facts

Study ID

NCT07475481

Run by

Charles University, Czech Republic

People needed

120

Starts

2027-07-01

Expected to finish

2030-03-31

Last updated by the study team

2026-03-16

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic low back pain lasting more than 12 weeks, with current low back pain at screening/baseline.
• Resting blood pressure below 139/89 mmHg.
• Health status allowing participation in moderate-intensity resistance training and aerobic activity.
• Physically active, but not professional athletes.
• Non-smoker.
• Able and willing to provide written informed consent and comply with study procedures

You may not qualify if…

• Absolute or relative contraindications to resistance training or other clinically relevant cardiovascular contraindications.
• Coronary artery disease, heart rhythm disorders, acute myocarditis, Marfan syndrome, or other cardiovascular conditions judged unsafe by the study physician.
• History of myocardial infarction, cerebrovascular disease, peripheral vascular disease, or grade II-IV hypertension.
• Type 1 or type 2 diabetes mellitus.
• Severe obesity (BMI >= 40.0 kg/m2).
• Infectious disease at screening (for example, COVID-19 or influenza).
• Current treatment for chronic low back pain from another healthcare provider.
• Prior spine surgery or lower-limb surgery.
• Structural spinal deformity such as spondylolisthesis or spondylolysis.
• Spinal fracture, inflammatory spinal disorder, or neurological signs of nerve root compromise, including decreased tendon reflexes, sensory loss, or motor deficits.
• Dizziness during exercise.
• Use of medications other than analgesics and non-steroidal anti-inflammatory drugs, unless specifically approved by the study physician.

Where it is running

• Faculty of Physical Education and Sport, Chrales University — Prague, Czechia

Full record on ClinicalTrials.gov

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