BLOOD-dose: A Platform Trial Evaluating Dose Optimization in Hematological Diseases.

Starting soon · Phase 4

Conditions studied: Waldenstrom Macroglobulinaemia, Multiple Myeloma

In brief

BLOOD-dose is a multicentre, adaptive, randomized, multidomain platform trial designed to optimize treatment dosing strategies in adult patients with haematological diseases. The BLOOD-dose core protocol outlines the overall clinical trial design that applies to all included interventions, while domain-specific appendices (DSA) detail the unique characteristics of each domain and specify domain-specific interventions. New domains will be incorporated over time to address distinct dose-optimization research questions across different haematological conditions and interventions.

Key facts

Study ID

NCT07474961

Run by

Anne Louise Tølbøll Sørensen

People needed

400

Starts

2027-03-01

Expected to finish

2036-12-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants of any sex who are at least 18 years of age at the time of providing informed consent.
• Participant diagnosed with a haematological disease, i.e. any disorder that primarily affects the blood, bone marrow, the lymphatic system and/or blood-forming organs.
• Should be eligible for participation in at least one of the currently active domains.
• Capable of giving signed informed consent for each applicable DSA(s). By consenting to a domain, participants also consent to participation in BLOOD-dose.

You may not qualify if…

• The participant tient is expected to live less than 3 months, as judged by the investigator.
• Any condition that, in the opinion of the investigator, impairs the participant's ability to understand trial procedures, provide informed consent and/or interfere with participation and/or compliance in the trial.
• Domain eligibility criteria: each domain has its own specific eligibility criteria detailed in each DSA.

Where it is running

• Copenhagen University Hospital - Rigshospitalet — Copenhagen, Greater Copenhagen Area, Denmark
• Aalborg University Hospital — Aalborg, Denmark
• Aarhus University Hospital — Aarhus, Denmark
• Odense University Hospital — Odense, Denmark
• Roskilde University Hospital — Roskilde, Denmark

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.