Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids

Starting soon · Phase 3

Conditions studied: Carpal Tunnel Syndrome (CTS)

In brief

This study compares the effectiveness of two types of local injections-Hyaluronic Acid (HA) and corticosteroids-for treating mild to moderate idiopathic Carpal Tunnel Syndrome (CTS). Sixty adult patients will be assigned to receive one of the two injections under ultrasound guidance. The goal is to see if HA is as effective as the standard corticosteroid treatment in improving symptoms and nerve function over a 3-month follow-up period.

Key facts

Study ID

NCT07474714

Run by

Minia University Hospital

People needed

60

Starts

2026-02-01

Expected to finish

2026-09-01

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Numbness or pain in the Median Nerve (MN) distribution.
• Nerve conduction studies (NCS) consistent with CTS as per the AANEM guidelines.
• An MN cross-sectional area (CSA) at the wrist >12 mm²

You may not qualify if…

• Patients with severe symptoms (indication for surgery).
• Patients who show improvement on medical treatment.
• Patients with previous surgical or injectional CTS treatment.
• Coexistence of brachial plexopathy, or thoracic outlet syndrome.
• Patients with infection at the site of injection.

Where it is running

• Minia University Hosopital — Minya, Egypt

Full record on ClinicalTrials.gov

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