Effects of Nicotine Dependence on Multidimensional Health Outcomes
Starting soon · Not applicable
Conditions studied: Tobacco Use Disorder, Nicotine Dependence, Cigarettes
In brief
Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects. Beyond its addictive potential, chronic nicotine exposure may induce inflammation, oxidative stress, tissue hypoxia, and autonomic imbalance, potentially impairing respiratory muscle strength, functional capacity, and overall physical performance. Additionally, nicotine dependence has been associated with sleep disturbances, cognitive dysfunction, altered pain perception, and reduced quality of life. Although previous studies have examined individual effects of smoking on specific health outcomes, research addressing these multidimensional impacts within a comprehensive framework remains limited. Therefore, this study aims to investigate the relationship between nicotine dependence level and respiratory muscle strength, functional capacity, cognitive functions, pain, quality of life, physical activity level, and sleep quality, in order to provide a more holistic understanding of the clinical consequences of nicotine dependence.
Key facts
- Study ID
- NCT07474623
- Run by
- Izmir Democracy University
- People needed
- 212
- Starts
- 2026-04-15
- Expected to finish
- 2027-07-15
- Last updated by the study team
- 2026-03-16
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Regular cigarette use for at least the past 6 months
- No history of respiratory, cardiovascular, or neurological/psychiatric disease
- No recent history of surgery or trauma that could affect respiratory muscles
- No current acute infection (especially upper or lower respiratory tract infections)
You may not qualify if…
- Presence of chronic respiratory diseases such as COPD or
- History of cardiovascular disease
- Diagnosed neurological or psychiatric disorders
- history of surgery or trauma affecting the respiratory muscles within the last 3 months
- Pregnancy or suspected pregnancy
Where it is running
- Betül TAŞPINAR — Konak, İ̇zmi̇r, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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