Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid

Starting soon · Not applicable

Conditions studied: Periodontitis

In brief

The goal of this clinical trial is to learn if using sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in adults. It will also learn about the safety of these treatments. The main questions it aims to answer are: Does the adjunctive treatment reduce bleeding on probing, plaque index, and periodontal pocket depth? What medical or dental problems do participants have when receiving these treatments? Researchers will compare: Standard non-surgical periodontal therapy alone Standard therapy plus sodium hypochlorite/amino acid gel Standard therapy plus sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid ("Clean and Seal" protocol) Participants will: Receive their assigned treatment during one clinical session per the study protocol Have clinical measurements taken before treatment and at three months after treatment Be monitored for any dental or medical adverse events related to the procedures

Key facts

Study ID

NCT07474272

Run by

Marwan El Mobadder

People needed

78

Starts

2026-03-11

Expected to finish

2026-08-01

Last updated by the study team

2026-03-17

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Localized periodontal pocket with a probing depth ≥ 6 mm and a clinical - attachment loss of > 3 mm (periodontitis stage III or IV; classification of the European Federation of Periodontology and American Academy of Periodontology);
• Patients who signed the written informed consent and is willing to cooperate;
• Bleeding on probing in more than 30% of the sites.

You may not qualify if…

• Medical history likely to affect periodontal status and/or to compromise treatment outcomes;
• Patients who received antibiotic and/or anti-inflammatory treatments the last 6 months
• Patients who received immunosuppressors treatments the last 6 months;
• Patients who received any periodontal therapy for the last 6 months;
• Pregnant or lactating women;
• Smokers smoking more than 10 cigarettes per day.

Where it is running

• Dental Specialist' DS — Sidon, South of Lebanon, Lebanon

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.