AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment

Enrolling by invitation · Not applicable

Conditions studied: Mild Cognitive Impairment (MCI)

In brief

Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health. This randomized controlled trial will evaluate the safety and efficacy of a 12-month artificial intelligence (AI)-supported cognitive rehabilitation program for older adults with MCI. Participants will be recruited from an existing research study conducted within Kaiser Permanente Southern California and randomized 1:1 to either (1) AI-supported cognitive rehabilitation or (2) usual care alone. The intervention combines clinician-delivered telehealth cognitive rehabilitation sessions with daily AI-guided cognitive exercises and education. The primary outcome is change in global cognition at 6 months measured by the Montreal Cognitive Assessment (MoCA)-BLIND. Secondary outcomes at 6 and 12 months include additional measures of cognition, subjective memory, goal attainment, mood, and loneliness. Exploratory outcomes include engagement with the AI intervention and health-related behavioral outcomes derived from electronic health record data. Participant safety will be monitored throughout the study through adverse event tracking, review of AI interactions for safety concerns, and predefined procedures for responding to psychological or clinical risk. This study will determine whether integrating AI-guided cognitive exercises with clinician-delivered rehabilitation improves cognitive and related outcomes in older adults with MCI compared to usual care.

Key facts

Study ID

NCT07474038

Run by

Kaiser Permanente

People needed

130

Starts

2026-03-16

Expected to finish

2027-12-31

Last updated by the study team

2026-03-20

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65 years or older
• Diagnosis of mild cognitive impairment (MCI)
• Montreal Cognitive Assessment (MoCA)-BLIND adjusted score (13-18)
• Able to provide informed consent
• English fluency sufficient to complete study assessments and participate in intervention sessions
• Access to and ability to use a computer or mobile device with internet connectivity

You may not qualify if…

• Current receipt of ongoing behavioral health treatment or psychotherapy from a Kaiser Permanente clinician
• Diagnosis of bipolar disorder, schizophrenia spectrum disorder, or other serious mental illness that would interfere with participation
• Significant communication impairment that would prevent participation in conversational or telehealth sessions

Where it is running

• Kaiser Permanente Southern California — Pasadena, California, United States

Full record on ClinicalTrials.gov

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