Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention
Recruiting now
Conditions studied: HIV Infections
In brief
The goal of this observational study is to generate real-life information on the use of lenacapavir (LEN, YEZTUGO®, (YTG)) for pre-exposure prophylaxis (PrEP) across diverse clinical settings in the United States. The study will characterize how PrEP is initiated, used, and discontinued in routine clinical practice when LEN is added as PrEP option and will evaluate persistence on LEN PrEP. The primary objective of this study is to evaluate real-life persistence on LEN PrEP at Week 52 in diverse clinical settings in the United States.
Key facts
- Study ID
- NCT07473778
- Run by
- Gilead Sciences
- People needed
- 3000
- Starts
- 2026-03-17
- Expected to finish
- 2029-04-01
- Last updated by the study team
- 2026-07-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UAB 1917 Research Clinic — Birmingham, Alabama, United States (enrolling)
- Pacific Oaks Medical Group — Beverly Hills, California, United States (enrolling)
- Ruane Clinical Research Group Inc. — Los Angeles, California, United States (enrolling)
- Family Health Centers of San Diego — San Diego, California, United States (enrolling)
- UC San Diego (UCSD) AntiViral Research Center (AVRC) — San Diego, California, United States (enrolling)
- Mills Clinical Research — West Hollywood, California, United States (enrolling)
- Vivent Health — Denver, Colorado, United States (enrolling)
- Bliss Health — Orlando, Florida, United States (enrolling)
- Pineapple Healthcare Orlando — Orlando, Florida, United States (enrolling)
- AHF - Pensacola — Pensacola, Florida, United States (enrolling)
- Faebris Medical & Community Education — Atlanta, Georgia, United States (enrolling)
- DOM/Project WISH Research Clinic — Chicago, Illinois, United States (enrolling)
- Howard Brown Health — Chicago, Illinois, United States (enrolling)
- The Clinic NOLA — New Orleans, Louisiana, United States (enrolling)
- Chase Brexton Health Care — Baltimore, Maryland, United States (enrolling)
- Fenway Health — Boston, Massachusetts, United States (enrolling)
- Be Well Medical Center — Berkley, Michigan, United States (enrolling)
- Henry Ford Health — Detroit, Michigan, United States (enrolling)
- The Aliveness Project — Minneapolis, Minnesota, United States (enrolling)
- KC Care Health Center — Kansas City, Missouri, United States (enrolling)
- Washington University School of Medicine Infectious Disease Clinical Research Unit — St Louis, Missouri, United States (enrolling)
- University of Nebraska Medical Center/Nebraska Medicine Specialty Care Center — Omaha, Nebraska, United States (enrolling)
- NYC Health + Hospitals / Bellevue — New York, New York, United States (enrolling)
- University of Cincinnati College of Medicine — Cincinnati, Ohio, United States (enrolling)
- Ohio State University Infectious Diseases Clinical Trials Unit — Columbus, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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