Essential Oil Inhalation and Acute Stress Response in Healthy Adults
Running, not enrolling · Not applicable · Has a placebo group
Conditions studied: Psychological Stress
In brief
This randomized, double-blind, placebo-controlled study evaluates the acute physiological and subjective responses to essential oil inhalation in healthy adults. Participants are assigned to inhale either an essential oil or a placebo via an aroma stick during standardized laboratory procedures designed to induce temporary psychosocial stress (Trier Social Stress Test - Group version) and during a guided relaxation session. Physiological responses, including heart rate, heart rate variability, and electrodermal activity, are measured using a wearable sensor. Subjective stress and affect are assessed using validated questionnaires and visual analog scales. The purpose of this study is to characterize short-term autonomic and self-reported responses associated with essential oil inhalation under controlled experimental conditions. This study is exploratory and is not intended to diagnose, treat, or prevent any medical condition.
Key facts
- Study ID
- NCT07473544
- Run by
- dōTERRA International
- People needed
- 200
- Starts
- 2026-03-10
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-05-12
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-45 years, inclusive
- Able to read, write, and understand English
- Willing and able to provide informed consent
- Willing to attend two in-person study visits
- Generally healthy, as determined by medical history and screening review
You may not qualify if…
- Known asthma, chronic obstructive pulmonary disease (COPD), significant lung disease, heart disease, or other medical condition that may compromise safety or data integrity
- Pregnancy or pregnancy within the past 90 days
- Known allergy or sensitivity to essential oils or study placebo materials
- Current smoking, vaping, chewing tobacco, or use of recreational drugs
- Regular use of essential oils applicable to the study phase (>3 times per week for ≥2 weeks within the past month) without a minimum 1-month washout
- Unwillingness to abstain from alcohol for at least 72 hours prior to each study visit
- Failure to meet inclusion criteria
Where it is running
- dōTERRA International — Pleasant Grove, Utah, United States
Full record on ClinicalTrials.gov
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