Retinal Oxygen Metabolism in Children With Myopia

Starting soon

Conditions studied: Myopia

In brief

The aim of the present study is to gain more information about retinal functional parameters in myopic children in Europe. For this purpose, a prospective case-control study in children aged between 8 and 13 years, as this is the usual age of myopia onset, will be conducted. Forty myopic children will be age- and sex-matched to non-myopic controls. Retinal oxygen extraction will be used as the main outcome parameter, as data from animal and human studies point towards an involvement of hypoxia in the disease process. In addition, other parameters probably linked to myopia will be investigated, such as retinal and choroidal blood flow as well as choroidal and retinal vessel density and anatomical structures such as choroidal and central retinal thickness. Also, questionnaires about lifestyle factors will be completed.

Key facts

Study ID

NCT07473401

Run by

Medical University of Vienna

People needed

80

Starts

2026-05-11

Expected to finish

2027-01-02

Last updated by the study team

2026-03-16

Who can join

Age: 8 and older, up to 13. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Intake of stimulating beverages containing xanthine derivatives (tea, coffee, cola-like drinks) 12 hours before the study day
• Previous eye abnormalities such as cataract, keratopathy, strabismus, amblyopia, ocular inflammation, trauma, or surgery
• History of any disease or syndrome associated with severe myopia such as Marfan syndrome, Stickler syndrome, or retinopathy of prematurity
• Non-axial cause of myopia
• BCVA less than 20/25
• Intraocular pressure ≥ 21mmHg
• Astigmatism ≤ -1.0dpt
• Anisometropia ≥ 2dpt
• Not able to read letters for visual acuity testing

Where it is running

• Department of Clinical Pharmacology, Medical University of Vienna, Austria — Vienna, Austria

Full record on ClinicalTrials.gov

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