Diagnostic Accuracy of Clinical Tests and Diagnostic Criteria for Piriformis Syndrome

Starting soon · Not applicable

Conditions studied: Piriformis Syndrome, Gluteal Pain

In brief

Piriformis syndrome is a clinical condition characterized by buttock pain and/or sciatic-like symptoms, and its diagnosis remains challenging because there is no universally accepted diagnostic standard. This study aims to evaluate the diagnostic accuracy of commonly used diagnostic criteria and clinical tests for piriformis syndrome. Participants with suspected piriformis syndrome will undergo standardized physical examination and assessment of predefined diagnostic criteria. Ultrasound-guided injection of 5 mL of 2% lidocaine into the piriformis muscle will be used as the reference diagnostic procedure. A reduction of 50% or more in pain after injection will be considered confirmation of piriformis syndrome. The diagnostic performance of clinical tests and diagnostic criteria will be analyzed accordingly.

Key facts

Study ID

NCT07473349

Run by

Istanbul University - Cerrahpasa

People needed

75

Starts

2026-03-15

Expected to finish

2026-09-15

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 75 years
• Presentation with gluteal pain
• Pain on palpation in the piriformis region

You may not qualify if…

• History of injection to the lumbar, hip, or gluteal region within the last 3 months,including steroid, hyaluronic acid, or similar injections
• History of hip surgery
• Presence of active inflammatory rheumatic disease, including rheumatoid arthritis, ankylosing spondylitis, polymyalgia rheumatica, vasculitis, or similar conditions
• Active skin or subcutaneous soft tissue infection in the gluteal region
• Use of anticoagulant therapy that may contraindicate injection
• Presence of a bleeding disorder
• Uncontrolled diabetes mellitus and/or hypertension
• History of neurological disease
• Pregnancy or lactation
• Presence of a psychiatric disorder
• Known allergy to the injection agents
• History of malignancy

Where it is running

• Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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