Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women
Recruiting now · Phase 4
Conditions studied: Overactive Bladder (OAB), Urge Incontinence
In brief
The goal of this clinical trial is to evaluate the effectiveness and safety of low-intensity shockwave therapy (Li-SWT) for the treatment of overactive bladder (OAB) in adult women. The main questions this study aims to answer are whether Li-SWT improves overactive bladder symptoms and quality of life, and whether these improvements are sustained over a 12-month follow-up period, compared with standard medical therapy. Researchers will compare Li-SWT with oral solifenacin succinate, a commonly used antimuscarinic medication for OAB. Participants will be randomly assigned to receive either Li-SWT once weekly for 8 weeks or solifenacin 5 mg taken orally once daily for 12 months. All participants will complete symptom questionnaires and three-day voiding diaries and will undergo uroflowmetry, post-void residual measurement, and filling cystometry at specified time points during follow-up.
Key facts
- Study ID
- NCT07473310
- Run by
- Mansoura University
- People needed
- 70
- Starts
- 2025-11-11
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-03-16
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- OAB symptoms persisting for ≥3 months.
- OAB Symptom Score (OABSS) ≥7.
- Ability and willingness to provide informed consent
You may not qualify if…
- Active urinary tract infection.
- Stress urinary incontinence as primary diagnosis.
- Pelvic organ prolapse stage ≥II.
- History of pelvic radiation or surgery within 6 months.
- Use of anticholinergics or β3-agonists for the past 4 weeks who are unwilling to undergo washout.
- Pregnancy or breast feeding.
- Neuropathic diseases or psychological disorders.
- History of urogenital malignancy.
- Uncontrolled DM (HbA1c > 6.8)
- Uncorrected coagulopathy or severe cardiovascular disease.
- Contraindication to solifenacin e.g.: closed angle glaucoma)
Where it is running
- Mansoura Faculty of medicine — Al Mansurah, Dakahlia Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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