The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.
Starting soon · Phase 4
Conditions studied: Vitiligo
In brief
The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo. It will also evaluate the safety of this treatment approach. The main questions it aims to answer are: * Does adding mini-oral pulse steroid therapy reduce the development of a perilesional halo after NCES surgery? * Does the addition of steroids improve the degree of repigmentation and overall treatment outcomes in vitiligo lesions? Researchers will compare NCES surgery with mini-oral pulse steroids to NCES surgery alone to determine whether the steroid therapy improves surgical outcomes. Participants will: * Undergo NCES vitiligo surgery for stable segmental or non-acral vitiligo lesions. * Be randomly assigned to receive either surgery alone or surgery plus low-dose oral mini-pulse dexamethasone therapy. * Attend follow-up visits and clinical assessments for approximately 4 months. * Receive excimer laser sessions twice weekly after healing and have standardized photographs and scoring assessments to evaluate repigmentation.
Key facts
- Study ID
- NCT07472816
- Run by
- Cairo University
- People needed
- 60
- Starts
- 2026-03-15
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2026-03-16
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with segmental vitiligo lesions that are not responsive to conventional treatment.
- Patients with non-Acral vitiligo lesions that are not responsive to conventional treatment and on sites known to be responsive to surgery, like the face and trunk.
- Stability for ≥ 1 year.
- Age ≥12 years.
- Lack of systemic and topical treatment for at least 3 months prior inclusion in the study.
You may not qualify if…
- Acral vitiligo.
- Segmental vitiligo lesions that are responsive to conventional treatment.
- Non acral vitiligo lesions on sites that are knowingly not responsive to surgery, like knees and elbows.
- Active vitiligo; new lesions, expansion of old lesions, confetti like lesions, ill-defined edges, hypochromia, depigmentation of previously pigmented areas or koebnerization in < 1 year.
- Age < 12 years.
- Pregnant females.
- Patients with contraindication to systemic steroid like uncontrolled hypertension, diabetes or tuberculosis
- Systemic and topical treatment in the past 3 months.
Where it is running
- Dermatology out patient clinic, Faculty of Medicine, Cairo University — Cairo, Egypt
Full record on ClinicalTrials.gov
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