Small Bowel Capsule Endoscopy in Lynch Syndrome

Recruiting now

Conditions studied: MMR Mutation, Small Bowel Adenoma, Small-bowel Adenocarcinoma, Lynch Syndrome, Cancer

In brief

The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.

Key facts

Study ID

NCT07472686

Run by

Assistance Publique - Hôpitaux de Paris

People needed

400

Starts

2025-06-16

Expected to finish

2026-12-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)
• Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine
• No opposition to the reuse of healthcare data for research purposes

You may not qualify if…

• Absence of documented MMR gene variant
• Opposition to the study

Where it is running

• Center for Digestive Endoscopy, Saint-Antoine Hospital — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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