MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI

Starting soon

Conditions studied: Acute Kidney Injury, Sepsis, Critical Illness, Renal Resistive Index

In brief

In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.

Key facts

Study ID

NCT07472452

Run by

Ankara Etlik City Hospital

People needed

130

Starts

2026-03-30

Expected to finish

2027-01-30

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥18 years
• Diagnosis of sepsis (per Sepsis-3 clinical criteria)
• RRI measurement feasible at bedside
• Informed consent from participant or legally authorized representative

You may not qualify if…

• End-stage kidney disease (chronic dialysis) or baseline eGFR <15mL/min/1.73 m²
• Kidney transplant recipient
• Anatomic/technical barrier precluding reliable renal Doppler (RRI) assessment
• Pregnancy

Full record on ClinicalTrials.gov

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