Validation on Clinical Adaptability of the Foundation Model Specific to Neuroimaging Diagnosis
Enrolling by invitation
Conditions studied: Central Nervous System Disease, MRI, CT, AI (Artificial Intelligence), Diagnose Disease, Classification
In brief
This clinic trial aims to investigate whether artificial intelligence (AI) diagnostic tools at neurological diseases diagnosis on brain CT/MRI can improve the work efficiency of specialized neuroimaging physicians, with a specific focus on its clinical value in distinguishing normal from abnormal findings, critical value identification, and neurological disease classification. Using pathological and/or discharge diagnoses of neurological diseases as the gold standard, an AI model will be trained on over 10,000 CT/MRI cases to achieve diagnostic performance comparable to that of neurological radiologists before being transformed and putted to use. Furthermore, clinical trials will be conducted in sub-studies (abnormal cases identification, critical value assessment, and neurological disease classification) to validate the clinical utility of AI and human-AI collaboration in the precise diagnosis of neurological disorders. The expected outcomes include reducing missed and misdiagnosis rates, enabling rapid screening of critical conditions, and achieving precise imaging-based diagnosis by using AI tools.
Key facts
- Study ID
- NCT07471984
- Run by
- Yaou Liu
- People needed
- 50000
- Starts
- 2025-05-01
- Expected to finish
- 2030-12-01
- Last updated by the study team
- 2026-03-13
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For MRI: patients suspected of harboring ischemic, hemorrhagic, brain tumors, degenerative brain disease, or traumatic brain injury at initiating or other institution, who subsequently underwent brain MRI;
- For CT: patients with or without neurological symptoms, suspected of harboring ischemic, hemorrhagic, space-occupying, degenerative brain disease, or traumatic brain injury, who subsequently underwent brain CT.
You may not qualify if…
- Exclusion Criteria:
- Patients who opted-out or did not give permission to reuse clinical data.
- Patients with a history of prior brain surgery.
- Patients whose brain CT or MRI exhibit severe artifacts (e.g. heavy warping due to air, metal artifacts, heavy motion artifacts), thereby impeding the usage of the data.
Where it is running
- Beijing Tiantan Hospital — Beijing, China
Full record on ClinicalTrials.gov
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