Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors
Recruiting now · Not applicable
Conditions studied: Cancer Survivorship, Family Planning, Adolescent and Young Adult Cancer
In brief
This study aims to develop and pilot-test a nurse navigator-delivered behavioral program to support female adolescent and young adult (AYA) cancer survivors in making informed, values-driven family-building decisions after completion of cancer treatment. Female AYA survivors often face fertility impairments, uncertainty about reproductive potential, elevated obstetric risks during pregnancy, and significant emotional distress related to parenthood planning. Currently, few interventions address these post-treatment decision-making needs. The intervention consists of four videoconference sessions that combine personalized, risk-based reproductive health education with coping strategies derived from Acceptance and Commitment Therapy and Patient Activation Theory. A pilot randomized controlled trial will evaluate feasibility, acceptability, and preliminary changes in knowledge, decisional conflict, self-efficacy, and reproductive-health-related distress among 48 participants randomized to the intervention or a survivorship-education control condition. Findings will inform future testing of the intervention's efficacy in a larger clinical trial.
Key facts
- Study ID
- NCT07471685
- Run by
- Duke University
- People needed
- 48
- Starts
- 2026-05-11
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older, up to 39. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female (biological sex) AYA cancer survivor age 15-39 at original diagnosis and 18-39 at enrollment.
- Completed cancer treatment with curative intent.
- Prior exposure to treatments posing gonadotoxic risk (e.g., alkylating agents, total body irradiation) and/or treatments increasing obstetric risk (e.g., chest radiation, radiation to uterus, anthracycline exposure).
- Has not completed family building.
- Able to speak/read English.
- Willing and able to complete videoconference sessions and REDCap surveys.
You may not qualify if…
- Visual, hearing, or cognitive impairment or severe mental illness that would interfere with participation as determined by study staff.
Where it is running
- Duke Cancer Institute — Durham, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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