Partial Thickness vs Full Thickness Tragal Cartilage Grafts in Endoscopic Type 1 Tympanoplasty

Starting soon

Conditions studied: Tympanoplasty Surgery

In brief

Primary Objective: Compare 6-month graft success rates between 0.5 mm sliced and 1.8 mm full-thickness tragal cartilage grafts.(3) H1: Sliced cartilage yields ≥90% success versus ≤80% for full-thickness.(3) H0: No difference between arms. Secondary Objectives: * PTA-ABG closure at 6/12 months.(4) * Speech discrimination score improvement.(4) * Operative time.(6)

Key facts

Study ID

NCT07471191

Run by

Assiut University

People needed

30

Starts

2026-04-01

Expected to finish

2028-05-01

Last updated by the study team

2026-03-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65 years.
• safe chronic perforation ≥6 months.
• Subtotal (25-75%) or large (>75%) pars tensa defect.
• Dry ear ≥3 months (culture-negative).
• Intact ossicles, healthy mucosa.
• Viable tragal cartilage.
• Informed written consent capability.

You may not qualify if…

• unsafe otitis,
• active discharge,
• Eustachian dysfunction e.g cleft palate,
• ossicular defects
• prior surgery,
• unfit patients
• non-compliance

Full record on ClinicalTrials.gov

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