A Study to Evaluate the Impact of a Magnolia Officinalis Dietary Supplement on Immune Biomarkers in Subjects With Psoriasis

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Psoriasis

In brief

The goal of this clinical trial is to evaluate whether Viv, a consumer-grade dietary supplement derived from the Magnolia officinalis plant, has an effect on biomarkers of immune activity in adults with psoriasis. To address this question, this trial will compare Viv to a placebo (a look-alike substance that contains no drug). Participants will: * Take Viv or a placebo every day for 3 months. * Complete electronic questionnaires about their quality of life and psoriasis symptoms at the beginning of the study and again at 1 months and 3 months. * Be provided with at home blood collection kits, which they will use to collect blood at the beginning of the study and again at 1 months and 3 months. Researchers will analyze these blood samples to measure the levels of specific inflammatory proteins and evaluate how they change over the course of the study in the participants taking Viv compared to those taking placebo.

Key facts

Study ID: NCT07471048
Run by: Sirt3 LLC
People needed: 100
Starts: 2026-03-01
Expected to finish: 2029-09-01
Last updated by the study team: 2026-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male of female, aged 18 years or older at time of consent.
Diagnosis of stable psoriasis affecting for at least 6 months confirmed by a dermatologist.
Patients with psoriasis-associated comorbidities including psoriatic arthritis are permitted, as long as those comorbidities are not severe enough to require treatment with systemic therapies as defined in the exclusion criteria.
Able to read and understand English.
Able to read, understand, and provide informed consent.
Able to use a personal smartphone device and download Chloe by People Science.
Able to receive shipment of the product at an address within the United States.
Able to adhere to study protocol (e.g., willing to collect and ship blood samples)

You may not qualify if…

Any potential participants who:
Do not have a personal smartphone, internet access, or unwilling to download Chloe.
Prior treatment with any systemic non-biologic immunosuppressive agents (e.g., methotrexate, cyclosporine, azathioprine) within 8 weeks prior to randomization.
Prior treatment with any systemic biologic therapies (e.g., guselkumab, risankizumab, ustekinumab, secukinumab, brodalumab, infliximab, adalimumab, golimumab, etanercept) within 6 months prior to randomization
Prior treatment with any other systemic investigational drugs within 6 months prior to randomization.
Other Illnesses or Conditions: Participants who have the following comorbidities or gastrointestinal illnesses are excluded:
Currently pregnant, planning to become pregnant in the next 3 months, or breastfeeding
Any underlying medical conditions or comorbidities that may confound the assessment of digestive symptoms or the evaluation of the study outcomes.
Have a significant illness, disease or condition which, in the opinion of the principal investigator, may impact their ability to participate in the study or impact the study outcomes.
Known hypersensitivity or previous allergic reaction to magnolia, rice or hypromellose.
Are unlikely for any reason to be able to comply with the trial or considered unsuited for participation in the study by the Principal Investigator.

Where it is running

Decentralized Study Coordinating Center — Englewood, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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