Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Recruiting now
Conditions studied: Type 1 Diabetes (T1D)
In brief
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets. This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function. The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.
Key facts
- Study ID
- NCT07470593
- Run by
- University Hospital, Strasbourg, France
- People needed
- 36
- Starts
- 2025-12-15
- Expected to finish
- 2029-12-15
- Last updated by the study team
- 2026-03-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥18 years old
- Insulin-dependent diabetes (type 1 diabetes, secondary to chronic pancreatitis, MODY, cystic fibrosis)
- Patient who has completed a full cycle of pancreatic islet transplantation, either:
- Islet Transplantation Alone (ITA), or
- Islet After Kidney (IAK), or
- Simultaneous Islet Kidney (SIK), with >10,000 IEQ/kg of recipient body weight, or <10,000 IEQ/kg but having achieved insulin independence
- Patient who has provided consent for reuse of their data for this research
You may not qualify if…
- Patient refusal to wear continuous glucose monitoring device
- Pancreatic islet autotransplantation
- Inability to provide informed consent (e.g., difficulties understanding study information)
- Patient under judicial protection (safeguard of justice)
- Patient under guardianship or curatorship
Where it is running
- Hopitaux Universitaires de Strasbourg — Strasbourg, France (enrolling)
Full record on ClinicalTrials.gov
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