Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
Recruiting now
Conditions studied: Differential Diagnosis, Diagnostic Accuracy
In brief
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations. The study combines retrospective analysis of existing publicly available image datasets with prospective data collection from licensed clinicians who complete diagnostic evaluation tasks. In the One-Shot Vision Differential Evaluation (OSVDE) stage, clinicians review individual de-identified medical images and generate a ranked list of potential diagnoses based solely on visual features. In the Multi-Step Conversational Non-Inferiority Evaluation (MSCNE) stage, clinicians complete diagnostic assessments using semi-synthetic patient simulations derived from de-identified medical images. Clinician performance will be compared with the AI system on the same diagnostic tasks. Human participants consist solely of licensed clinicians who provide diagnostic responses. Medical images and simulated cases are study materials and are not considered study participants. No identifiable patient data are used, and the AI system is evaluated in an offline research environment and is not used for clinical decision-making or patient care.
Key facts
- Study ID
- NCT07470463
- Run by
- Magic Health Inc. (d.b.a. Nolla Health)
- People needed
- 30
- Starts
- 2026-03-19
- Expected to finish
- 2026-09-19
- Last updated by the study team
- 2026-03-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Active license in Dermatology, Internal Medicine, Otolaryngology, Gynecology, Orthopedics, Pediatrics, Geriatrics, Emergency Medicine, Ophthalmology, Psychiatry, Endocrinology, Family Medicine, or a closely related specialty
- Age 18 years or older
- Ability to complete diagnostic evaluation sessions remotely using a computer or tablet with reliable internet access
You may not qualify if…
- Loss of active license in an eligible specialty
- Inability to complete the evaluation session remotely
Where it is running
- Nolla Health (Magic Health Inc.) — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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