The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Neural Inhibition, Anxiety, Depression

In brief

This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.

Key facts

Study ID

NCT07469462

Run by

University of Reading

People needed

44

Starts

2026-05-01

Expected to finish

2026-11-01

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older, up to 41. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Over 18 years of age and under 41
• Mild to moderate anxiety and/or depression
• Normal or corrected to normal vision

You may not qualify if…

• not taking daily dietary supplement containing >2 mg Vitamin B6
• not taking medication that is a GABA agaonist (our team will check this with you)
• not be pregnant
• no medical history of epilepsy
• no medical history of peripheral neuropathy
• not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)
• no history of brain injury or recent concussion

Where it is running

• Harry Pitt Building — Reading, England, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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