Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery

Starting soon · Not applicable

Conditions studied: Postoperative Recovery, PONV

In brief

Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies. This prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.

Key facts

Study ID

NCT07469332

Run by

Ankara City Hospital Bilkent

People needed

135

Starts

2026-03-30

Expected to finish

2026-07-30

Last updated by the study team

2026-03-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 and 65 years
• ASA physical status I-II
• Scheduled for elective laparoscopic cholecystectomy
• Undergoing general anesthesia
• Ability to provide written informed consent

You may not qualify if…

• Patients younger than 18 years or older than 65 years
• Known allergy to dexamethasone
• ASA physical status III or higher
• Surgical procedures lasting longer than 120 minutes
• Emergency surgeries
• Pregnant or breastfeeding patients
• Patients with coagulopathy or receiving anticoagulant therapy
• Known allergy to local anesthetics
• Localized infection at the injection site
• Inflammatory bowel disease
• Autoimmune diseses
• Chronic pain conditions
• Ocular herpes simplex infection
• Cushing's disease
• Myasthenia gravis
• Anticipated poor compliance with the study protocol
• Vaccination within the last 14 days
• Use of systemic glucocorticoids or immunosuppressive drugs
• İmpaired renal function (GFR < 30 mL/min)
• Liver cirrhosis
• Congestive heart failure
• Peripheral nerve disorders
• Elective laparoscopic cholecystectomy due to malignancy
• Conversion to open surgery during the operation
• Epilepsy

Where it is running

• Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation — Ankara, Çankaya, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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