High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea

Starting soon · Not applicable

Conditions studied: Obesity, Class III, Sleep Apnea, Obstructive, Inspiratory Muscle Training

In brief

The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg/m²) and obstructive sleep apnea (OSA). Using a single-case experimental design (SCED) with multiple baselines, the study will investigate whether this respiratory intervention can reduce the severity of sleep apnea, as measured by the Apnea-Hypopnea Index (AHI), and improve inspiratory muscle strength and sleep quality. Participants will perform daily training sessions using a resistive loading device (POWERbreathe), with intensity progressing from 40% to 90% of their maximum inspiratory pressure.

Key facts

Study ID

NCT07469280

Run by

University of the State of Santa Catarina

People needed

10

Starts

2026-05-01

Expected to finish

2027-12-01

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Systemic diseases (pulmonary, cardiac or renal).
• Are using medications that may affect muscle performance.
• Are currently using CPAP therapy.
• Conditions that could compromise adherence to the study protocol.

Where it is running

• Santa Catarina State University - CEFID (Center of Health and Sport Sciences) — Florianópolis, Santa Catarina, Brazil

Full record on ClinicalTrials.gov

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