Feasibility Study of Urinary cfDNA Analysis as a Non-invasive Monitoring Tool in Patients With Prostate or Bladder Cancer
Starting soon
Conditions studied: Prostate Cancer, Bladder Cancer
In brief
The UroDNA study is a feasibility study (RIPH category 3) aimed at evaluating the analysis of circulating tumour DNA in urine (urinary cfDNA) as a non-invasive monitoring tool in patients with prostate or bladder cancer. Urine samples will be collected at different times during the course of treatment to define the optimal conditions for cfDNA collection, extraction and analysis, and to explore the detection of tumour mutation profiles. This study does not involve any experimental treatment. Its objective is to validate the technical and clinical feasibility of a molecular monitoring urine test, which could offer a simple and non-invasive alternative to improve the management of urological cancers.
Key facts
- Study ID
- NCT07468838
- Run by
- Institut Cancerologie de l'Ouest
- People needed
- 25
- Starts
- 2026-05-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-03-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Five patients for each of the following cancers :
- Patients with high-risk localised prostate cancer eligible for high-dose radiotherapy, or
- Patients with mHSPC eligible for docetaxel chemotherapy, or
- Patients with mCRPC in second-line treatment eligible for luPSMA treatment, or
- Patients with localised bladder cancer eligible for neoadjuvant chemotherapy or,
- Patients with metastatic bladder cancer eligible for enfortumab vedotin (EV) plus pembrolizumab (EV-Pembro)
You may not qualify if…
- History of cancer in the 5 years prior to entering the trial other than basal cell skin cancer or cervical carcinoma in situ,
- Women who are pregnant, likely to become pregnant or breastfeeding,
- Persons deprived of their liberty, under judicial protection, under guardianship or placed under the authority of a guardian, Inability to undergo medical follow-up for the trial for geographical, social or psychological reasons.
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.