Development of an Innovative Method to Extract Cord Blood Stem Cells With High Efficiency

Recruiting now

Conditions studied: HSCs Extraction

In brief

The present study has the purpose to develop an innovative method for obtaining HSCs with a high yield. HSCs extracted from UCB using the traditional method followed by several steps of centrifugation will be compared to the new method which exploit a new biocompatible liquid, capable to separate the HSCs without causing mechanical stress to cells. The potential of ozone treatment to stimulate cells proliferation will be also assessed. Since ozone has been identified as an adjuvant to sustain cytoprotective pathways increasing cell performance, HSCs obtained from UCB samples will be treated by flowing ozone at low concentrations (between 2 and 20 μg/mL) in a mixture 1:1 with oxygen.

Key facts

Study ID

NCT07468201

Run by

Fondazione IRCCS Policlinico San Matteo di Pavia

People needed

12

Starts

2024-04-10

Expected to finish

2026-04-10

Last updated by the study team

2026-03-12

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy women who have signed the informed consent for umbilical cord donation for research purposes

You may not qualify if…

• Women with inability to comply with the requirements of the protocol and presence of viral infections.

Where it is running

• Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Lombardy, Italy (enrolling)

Full record on ClinicalTrials.gov

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