Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children

Recruiting now

Conditions studied: Respiratory Insufficiency in Children

In brief

Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling. However, the accuracy of tPCO₂ may be influenced by factors such as peripheral perfusion, skin temperature, and vasopressor therapy. This prospective observational study compares transcutaneous carbon dioxide measurements with arterialized or arterial blood gas PaCO₂ values in children with respiratory insufficiency, including a subgroup receiving vasopressor support.

Key facts

Study ID

NCT07468006

Run by

Brno University Hospital

People needed

20

Starts

2026-01-01

Expected to finish

2028-01-31

Last updated by the study team

2026-03-12

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 1-18 years
• Diagnosis of respiratory insufficiency or impaired peripheral perfusion
• Expected need for more than one arterialized capillary or arterial blood gas sample
• Admission to PICU

You may not qualify if…

• Repeated failure of sensor adhesion
• Hypothermia < 35 °C
• Time difference > ±5 minutes between tPCO₂ and blood sampling
• Large tPCO₂ variability (> ±1 kPa) in 15 minutes preceding blood sampling
• Non-physiological tPCO₂ values incompatible with life

Where it is running

• University Hospital Brno — Brno, Czechia (enrolling)

Full record on ClinicalTrials.gov

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