A Proof-of-concept Study of Ultrasound Stimulation of the Neck to Enhance Anti-shock Efficacy
Starting soon · Not applicable
Conditions studied: Shock
In brief
The objective of this clinical study is to evaluate the initial efficacy and safety of LIPUS as an adjunct to standard therapy in patients with shock. The investigators will invite patients to participate in a proof-of-concept study investigating the efficacy of neck ultrasound stimulation to enhance anti-shock treatment, involving brief exposure to low-intensity pulsed ultrasound. This study examines whether LIPUS can enhance blood pressure in patients with shock, improve the efficacy of antihypotensive treatment, and reduce the dosage and duration of vasoactive drugs during active pharmacological therapy. By applying LIPUS as an adjunct to conventional treatment in clinical cases of shock, we aim to determine the clinical value of LIPUS and establish a theoretical foundation for developing innovative new therapies for shock.
Key facts
- Study ID
- NCT07467798
- Run by
- Tao Liu
- People needed
- 30
- Starts
- 2026-05-01
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-04-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with shock who are ≥18 years of age and have a systolic blood pressure (SBP) between 60 mmHg and 90 mmHg;
- Patients with arterial blood pressure monitoring or peripheral arterial pressure monitoring with intervals of single-digit minutes;
- Patients with mild to moderate shock with a shock index (SI) of 1 ≤ SI ≤ 2;
- Patients with complete medical records.
You may not qualify if…
- Patients with unstable condition and estimated survival time <24 hours;
- Patients requiring emergency surgery to achieve control of their condition;
- Perioperative patients requiring surgery due to conditions other than hypotension;
- Pregnant or lactating patients;
- Patients with neck wounds and/or carotid artery plaques who are unsuitable for ultrasound stimulation of the left carotid sinus;
- Patients deemed unsuitable for inclusion by the investigator.
Full record on ClinicalTrials.gov
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