Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome

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Conditions studied: Irritable Bowel Syndrome

In brief

This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS). Twenty-four patients diagnosed with IBS according to the Rome IV criteria were randomized to either a Low-FODMAP diet or a traditional diet for four weeks. Stool zonulin family peptides (ZFP), IBS Symptom Severity Score (IBS-SSS), and IBS Quality of Life (IBS-QOL) questionnaires were recorded at baseline and after the dietary intervention. In the Low-FODMAP group, FODMAP-containing foods were gradually reintroduced under dietitian supervision, and assessments were repeated at week 16 to evaluate long-term effects.

Key facts

Study ID

NCT07467278

Run by

Istanbul Medipol University Hospital

People needed

24

Starts

2026-03-15

Expected to finish

2026-08-30

Last updated by the study team

2026-03-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• IBS-specific treatment within the last 1 month
• Antibiotic or probiotic use within the previous 2 weeks
• History of major abdominal surgery
• Active malignancy
• Heart failure
• Renal failure
• Autoimmune disease
• Inflammatory bowel disease
• Celiac disease
• Lactose intolerance
• Individuals currently following another dietary regimen
• Pregnancy
• Poor adherence to diet protocol (<51%)
• Failure to submit dietary diaries regularly
• Need for antibiotic therapy during the intervention period

Full record on ClinicalTrials.gov

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