Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction

Recruiting now · Phase 3

Conditions studied: Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding

In brief

This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) and being treated with dual antiplatelet therapy (DAPT).

Key facts

Study ID

NCT07467213

Run by

Samsung Medical Center

People needed

5000

Starts

2026-06-23

Expected to finish

2030-12-31

Last updated by the study team

2026-06-26

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 19 years or older.
• Patients diagnosed with acute myocardial infarction (ST-segment elevation myocardial infarction [STEMI] or non-ST-segment elevation myocardial infarction [NSTEMI]).
• Patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) or drug-coated balloons (DCB).
• Patients (or their legal representatives) who understood the study risks and benefits and provided voluntary written informed consent.

You may not qualify if…

• History of hypersensitivity (e.g., allergic reaction, anaphylactic shock) or contraindication to study drugs (potassium-competitive acid blocker [P-CAB] or proton pump inhibitor [PPI]).
• Presence of active gastrointestinal bleeding.
• Pregnant or breastfeeding women.
• Non-cardiac life expectancy of less than 1 year or patients expected to have low compliance (as determined by the investigator's medical judgment).
• Patients who refuse to participate or are unable to follow the requirements specified in the study protocol.

Where it is running

• Samsung Medical center — Seoul, South Korea (enrolling)

Full record on ClinicalTrials.gov

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