A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers
Starting soon
Conditions studied: Intracranial Venous Blood, Brain Cancers, Liquid Biopsy, Evaluate the Safety
In brief
To learn if drawing blood directly from veins inside the brain is safe and can effectively provide the same kind of detailed information about high-grade glioma as traditional surgical biopsy.
Key facts
- Study ID
- NCT07467109
- Run by
- M.D. Anderson Cancer Center
- People needed
- 20
- Starts
- 2026-08-19
- Expected to finish
- 2029-05-01
- Last updated by the study team
- 2026-03-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Subjects with suspected glioma or other brain cancers who do not have a tissue diagnosis and no surgical biopsy or resection is anticipated.
- Subjects in whom diagnostic cerebral angiogram is contra-indicated defined as:
- Severe contrast allergy
- Acute/chronic renal dysfunction with eGFR < 45 ml/min and Cr ≤ 1.5 mg/dL
- For participants undergoing surgery, refractory coagulopathy or thrombocytopenia which cannot be corrected defined as:
- Platelets ≤100,000/mcL
- International Normalized Ratio ≤ 1.7
- Subjects that have a known high risk in monitored anesthetic care or general anesthesia assessed by the treating physician.
- Anatomic considerations: based on cross-sectional imaging such as CT angiogram of the head and neck, the anatomy for arterial and venous vascular access is deemed unsuitable for endovascular access such as high-grade carotid artery stenosis, absent or occluded internal jugular veins, sigmoid sinuses and/or transverse sinuses.
- Participants with clinical cerebral edema evidenced from altered mental status
- Pregnant women due to risk of radiation exposure to the fetus, as determined by pregnancy urinalysis or serum analysis test during screening.
- Subjects with psychiatric illness/social situations that would limit compliance with study requirements at the physician's discretion.
Where it is running
- MD Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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