Optimisation of Solute Removal and Water Usage in Paediatric Haemodialysis

Enrolling by invitation · Not applicable

Conditions studied: Pediatric, Efficiency, Hemodialysis Patient, Hemodialysis Treatment

In brief

Children receiving chronic haemodialysis are typically treated with dialysis machines designed for adult patients. As a result, some devices do not allow the ideal blood or dialysate flow rates to be set for paediatric use. In addition, the optimal dialysate-to-blood flow ratio for maximising solute removal while minimising water consumption remains poorly defined. The aim of this study is to quantify the dialyser extraction ratio and clearance across different dialysis modalities and a range of dialysate-to-blood flow ratios. Blood and dialysate samples are collected at the blood inlet, blood outlet, and dialysate outlet lines, and concentrations of various uraemic toxins-spanning a range of molecular weights-are measured to calculate solute clearances.

Key facts

Study ID

NCT07466459

Run by

University Hospital, Ghent

People needed

10

Starts

2025-11-13

Expected to finish

2026-12-31

Last updated by the study team

2026-03-12

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• not older than 18 years old
• at least three months of stable hemodialysis

You may not qualify if…

• a non well-functioning vascular access
• infections at the study week

Where it is running

• Ghent University Hospital, Nephrology — Ghent, Belgium

Full record on ClinicalTrials.gov

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