L-serine and Strength Training in the Elderly

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Brain Health, Longevity, Cognitive Performance, Strength Training Effects, Healthy Ageing, Ageing, Cognition, Memory, Muscle Strength

In brief

This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.

Key facts

Study ID

NCT07466290

Run by

University of Vienna

People needed

126

Starts

2026-03-01

Expected to finish

2028-12-01

Last updated by the study team

2026-03-12

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women between the ages of 65 and 85
• Mini-Mental-State >23
• Independently mobile, without aids (walker, cane, etc.)

You may not qualify if…

• Chronic diseases that contraindicate medical training therapy
• Regular strength training (>1x/week) in the last 6 months before confinement
• Frailty Index ≥ 3
• Lack of written consent to test physical performance
• Regular use of Cortison-containing medications or Antibiotika
• MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body
• Non-compliance with the study protocol: <70% of the planned L-serine administration, <70% of the strength training

Where it is running

• NuTraLab — Vienna, State of Vienna, Austria (enrolling)

Full record on ClinicalTrials.gov

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