National Multicentre Study on Lipid Profile in Noonan Syndrome and Related Disorders: Trends by Age, Gender and Genotype

Recruiting now

Conditions studied: RASopathies, Noonan Syndrome

In brief

RASopathies, including Noonan syndrome, involve dysmorphisms, metabolic alterations, and an unfavorable lipid profile. This study investigates lipid and glucose metabolism to improve patient care.

Key facts

Study ID

NCT07464821

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

200

Starts

2025-02-26

Expected to finish

2027-04-26

Last updated by the study team

2026-03-11

Who can join

Age: 2 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically diagnosed RASopathy confirmed by molecular testing;
• Patients referred to participating centers between 01/01/2001 and 31/12/2022;
• Age at enrollment between 2 and 35 years, inclusive;
• Obtaining informed consent.

You may not qualify if…

• None.

Where it is running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (enrolling)
• AOU Meyer IRCCS — Florence, Italy (enrolling)
• IRCCS Istituto Giannina Gaslini — Genova, Italy (enrolling)
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy
• IRCCS Ospedale San Raffaele — Milan, Italy
• Azienda Ospedaliera Policlinico di Modena — Modena, Italy
• Fondazione IRCCS San Gerardo dei Tintori — Monza, Italy
• AOU Vanvitelli — Naples, Italy
• Azienda Ospedale-Università di Padova — Padova, Italy
• Azienda Ospedaliero-Universitaria di Parma — Parma, Italy
• Azienda Ospedaliero-Universitaria di Alessandria — Alessandria, Italy
• AOUI-VR Azienda Ospedaliero-Universitaria Integrata di Verona — Verona, Italy
• AOU Policlinico di Bari — Bari, Italy
• AOU Policlinico G. Martino — Messina, Italy

Full record on ClinicalTrials.gov

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