Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings
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Conditions studied: Esophageal Varices, Portal Hypertension
In brief
The goal of this observational study: * To evaluate the diagnostic accuracy of non-invasive markers in predicting the presence and grading of esophageal varices in children with portal hypertension. * To correlate these non-invasive markers with the severity of portal hypertension and the grade of esophageal varices to identify patients at high risk of bleeding. * To propose a defined protocol for screening esophageal varices in those children.
Key facts
- Study ID
- NCT07464522
- Run by
- Assiut University
- People needed
- 51
- Starts
- 2026-03-20
- Expected to finish
- 2028-05-20
- Last updated by the study team
- 2026-03-23
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged less than 18 years diagnosed with portal hypertension either due to hepatic or extrahepatic causes
You may not qualify if…
- Active variceal bleeding at presentation (hemodynamic instability affects platelet/spleen parameters).
- Previous history of variceal bleeding or endoscopic intervention (band ligation/sclerotherapy).
- Prior surgical portosystemic shunts or Transjugular Intrahepatic Portosystemic Shunt (TIPS).
- Current use of vasoactive drugs for primary prophylaxis (e.g., Non-selective beta-blockers).
- Systemic infections or hematological disorders causing independent thrombocytopenia or splenomegaly (to avoid confounding the platelet/spleen ratio).
Full record on ClinicalTrials.gov
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