Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries

Starting soon · Not applicable

Conditions studied: Driving Pressure, Neuromuscular Blockade Monitoring, Postoperative Respiratory Complications

In brief

This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients undergoing abdominal surgery under general anesthesia.

Key facts

Study ID

NCT07464288

Run by

Ankara City Hospital Bilkent

People needed

128

Starts

2026-03-23

Expected to finish

2026-04-24

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Elective abdominal surgery under general anesthesia that is expected to last longer than one hour
• ASA I-II-III
• Age ≥18 years
• Written informed consent

You may not qualify if…

• Refusal to participate in the study
• ASA ≥ IV
• Age <18
• Obesity (BMI>30) and cachexia (BMI <18)
• Laparoscopic surgery
• Emergency procedure
• Allergy to drugs used during induction and maintenance of general anesthesia
• Presence of psychiatric/neurologic/neuromuscular disease
• Risk of malignant hyperthermia or having any relative with history of malignant hyperthermia
• Use of medications that may affect neuromuscular function (anticonvulsants, aminoglycosides, magnesium salts, etc.)
• Pregnancy
• Presence of advanced chronic lung disease (asthma, COPD, etc.)
• Presence of advanced liver and renal disease (creatinine>1.6, liver function tests above twice the normal range)

Where it is running

• Ankara Bilkent City Hospital — Ankara, Çankaya, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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