Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards
Recruiting now · Not applicable
Conditions studied: Tooth Discoloration, Tooth Staining
In brief
This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.
Key facts
- Study ID
- NCT07464197
- Run by
- Universitat Internacional de Catalunya
- People needed
- 40
- Starts
- 2022-05-01
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2026-03-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18 years or older
- Good general and oral health
- No current medical treatment (self-reported)
- No need for surgical, endodontic, periodontal, or restorative dental treatment
- At least six upper and six lower anterior teeth free of caries and restorations
- Maxillary central incisors with baseline shade A2 or darker
- Willingness to follow the study protocol and use the study-provided oral hygiene products/instructions
You may not qualify if…
- Previous tooth bleaching treatment
- Orthodontic appliances or prostheses that interfere with treatment
- Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)
- Pregnancy or lactation
- Bruxism
- Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity
- Use of anti-inflammatory or analgesic medication during the study period (according to protocol)
Where it is running
- Clínica Universitària d'Odontologia UIC Barcelona — Sant Cugat del Vallès, BARCELONA, Spain (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.