Advanced Brain Imaging-TKA (fMRI-TKA)

Recruiting now · Not applicable

Conditions studied: Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction, Brain MRI

In brief

Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.

Key facts

Study ID

NCT07464080

Run by

Ottawa Hospital Research Institute

People needed

50

Starts

2026-04-01

Expected to finish

2028-12-31

Last updated by the study team

2026-03-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients aged 18 years or older
• Primary TKA
• Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis

You may not qualify if…

• Inability or refusal to sign informed consent form
• Non-English or French speaking, and no licensed translator, family member or substitute decision maker available
• History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis
• Cognitive impairment or dementia
• Revision and/or Bilateral TKA
• Chronic Opioid use

Where it is running

• The Ottawa Hospital — Ottawa, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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